楊慕華 Yang, Muh-Hwa
講座教授 / 陽明臨床醫學研究所![]() [ CV ]
Email: mhyang2@vghtpe.gov.tw
Tel: +886-2-2827-7000 ext.7911
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RESEARCH INTERESTS:Pleiotropic functions of EMT regulators during cancer metastasis Epithelial-mesenchymal transition (EMT) is one of the major mechanisms of cancer metastasis. However, the pleiotropic effects of EMT regulators in additional to the promotion of cellular migration have been investigated limitedly. We recently discover several novel functions of the EMT regulators during head and neck cancer progression. First, we confirm the direct regulation of the stemness-related gene BMI1 by the EMT regulator Twist1. Twist1 and BMI1 are mutually essential in promoting EMT and tumor-initiating capability. Second, we identify the mechanism of Twist1-induced motility through repressing microRNA let-7i and activating RAC1. Third, we show the induction of chromosomal instability by Twist1-BMI1 through upregulating Aurora A expression. In the future, we will keep focusing on the pleiotropic effects of EMT regulators during cancer metastasis and confirm their clinical significance.
EMT調控因子在腫瘤轉移時的功能多樣性 上皮細胞中胚轉化(epithelial-mesenchymal transition,EMT)是癌症轉移的主要機制之ㄧ,但產生EMT時,EMT調控因子除促進細胞移動外的多功能性尚未明瞭。我們近年的研究發現在頭頸癌細胞中,EMT調控因子在減低細胞結合及促進移動外,幾項重要的其他功能:Twist1會調控幹細胞基因BMI1並引發幹細胞生成; Twist1藉由抑制微型RNA let-7i表現,引發RAC1活化,使頭頸癌細胞在三維細胞培養系統中產生「間質型運動模式」;Twist1-BMI1會藉由誘發Aurora A 表現,使癌細胞產生染色體不穩定。未來我們將持續專注於癌症轉移時EMT調控因子的功能多樣性之機制研究,並且在臨床上印證其意義。 ![]() 瀏覽數
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