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謝世良教授 Hsieh, Shie-Liang

特聘研究員 / 中央研究院基因體研究中心

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[ CV ]
  • Email: slhsieh@gate.sinica.edu.tw
  • Tel: (02) 27871245

     

    EDUCATION AND POSITIONS

    • M.D., National Yang-Ming University, 1984
    • D.Phil., University of Oxford, UK, 1992
    • Postdoctoral fellow, Stanford University, 1993
    • Director, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan, 2010-2013
    • Department head, Department of Microbiology and Immunology, Natl. Yang-Ming Univ., Taipei, Taiwan, 2007-2013
    • Director, Immunology Research Center, Taipei Veterans’ General Hospital, Taiwan, 2005-2013Director, Immunology Research Center, Natl. Yang-Ming Univ., Taiwan, 2000-2013
    • Adjunct Senior Investigator, National Health Research Center, Taipei, Taiwan, from 2004
    • Adjunct Professor, Institute of Clinical Medicine, Natl. Yang-Ming Univ., Taipei, Taiwan, from 2013
    • Adjunct research fellow, Taipei Veterans’ General Hospital from 2013
    • Distinguished Research Fellow, Academia Sinica, Taipei, Taiwan, from 2013

    HONORS:

    • 1989 Oversea PhD studentship from the Ministry of Education, Taiwan P
    • 1989 Oversea Research Scholarship (ORS) from the University of Oxford P
    • 1992 Irvington Medial Foundation post-doctoral fellowship ‘Robert Wood Johnson Fellow P
    • 1999, 2003, 2010 Outstanding Researcher Award from the National Science Council P
    • Outstanding Alumni, National Yang-Ming University P
    • Outstanding research Achievement to National Health, “Ming-Ning Wang Memorial Foundation”, 2008 P
    • Tsungming Tu Award, Taiwan Medical Society, 2009 P
    • Long-Term Award from Acer Foundation, 2009 P
    • Academic Achievement Award, Ministry of Education, 2009 P
    • 2012 National Chair Professor Award, Ministry of Education P
    • 2013 TienTe Lee Award

    RESEARCH INTERESTS:

    Glycoimmunology

     

    Hsieh_Shie-Liang_pic01Research in the Hsieh lab encompasses the identification of glycans-binding proteins critical for host-pathogen interaction and immunomodulation, and production of monoclonal antibodies as potential novel therapeutic agents for anti-inflammation. New technology to detect weak interaction between glycans and lectins is developed to identify lectins receptors recognizing intact icosahedral virions, microparticles, microorganisms, and various glycoconjugates. Antagonistic bi-specific mAbs, and recombinant fusion proteins are being developed for immunomodulation to control aseptic and non-aseptic inflammatory diseases. Functions of novel polymorphic C-type lectins located in ER, Golgi and endosomes are being investigated systemically to reveal their impacts in the establishment of inflammatory reactions and human diseases.

     

    Glycoimmunology

     

    我們實驗室的研究包括了分析與宿主及病原體相互作用與免疫調節有關的聚醣接合蛋白其功能、及生產當作抗免疫反應治療標的之單株抗體。目前也已發展可用來偵測聚醣與凝集素之間微弱相互作用的新技術,並可利用此技術來分析可與完整二十面體的病毒顆粒、微粒子、微生物及不同的醣接合物接合的凝集素接受器。具有雙特異性的拮抗抗體及重組的融合蛋白目前也已被發展來控制感染性及非感染性的發炎疾病等等免疫調節目地。至於位於內質體、高基氏體及核內體等處的C型凝集素也因為其在發炎反應及人類疾病的重要角色,而被驗證其具有特殊多樣的功能。

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